I just got this yesterday and tested it on the base of my fave silicone butt plug and it did not have any adverse effect on it. I only tested it on the bottom with a small dab, but it seems to be safe to use with silicone toys. There's no warning on the bottle to suggest you should avoid use with silicone toys neither. I will report back if it turns out that it is no good with silicone after more use. I got this to use with other, non-silicone toys, and it's a bonus that I can use it with my fave butt plug. I also like that it looks like cum.